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Historically, possessing 5 grams of crack cocaine led to the same prison sentence as possessing 500 grams of powder cocaine (100:1 ratio)

doi: 10.1177/001789690106000406 88

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By comprehensively optimizing factors such as temperature, pH, dissolved oxygen levels, osmotic pressure, and medium composition, the efficiency of microbial nicotine degradation during fermentation can be significantly enhanced, thereby improving the overall quality of tobacco leaves and products